CHRDL2

Gene Symbol CHRDL2
Entrez Gene 25884
Alt Symbol BNF1, CHL2
Species Human
Gene Type protein-coding
Description chordin-like 2
Other Description breast tumor novel factor 1|chordin-like protein 2|chordin-related protein 2
Swissprots Q6WN32 Q6WN30 A5PKU9 Q7Z5J3 Q6WN31 Q6WN34
Accessions EAW74944 EAW74945 Q6WN34 AF332891 AAG50288 AK304519 BAG65323 AL047873 AL110168 CAB53666 AY163868 AAO31809 AY279090 AAQ19179 AY279091 AAQ19180 AY279092 AAQ19181 AY279093 AAQ19182 AY279094 AAQ19183 AY358522 AAQ88886 BC141564 AAI41565 BC142623 AAI42624 BC153100 AAI53101 BF437637 JN579714 AEV56635 NM_001278473 NP_001265402 NM_001304390 NP_001291319 NM_001304391 NP_001291320 NM_001304415 NP_001291344 NM_001304416 NP_001291345 NM_001304417 NP_001291346 NM_015424 NP_056239
Function May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation. {ECO:0000250, ECO:0000269|PubMed:12853144, ECO:0000269|PubMed:15094188}.
Subcellular Location Isoform 5: Cytoplasm {ECO:0000305}.
Tissue Specificity Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma. {ECO:0000269|PubMed:12853144, ECO:0000269|PubMed:14660436, ECO:0000269|PubMed:15094188}.

CHRDL2 CRISPR/Cas9 KO Plasmid (h) - sc-409248 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHRDL2 HDR Plasmid (h) - sc-409248-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHRDL2 Double Nickase Plasmid (h) - sc-409248-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHRDL2 Double Nickase Plasmid (h2) - sc-409248-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHRDL2 CRISPR Activation Plasmid (h) - sc-409248-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHRDL2 CRISPR Activation Plasmid (h2) - sc-409248-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHRDL2 Lentiviral Activation Particles (h) - sc-409248-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHRDL2 Lentiviral Activation Particles (h2) - sc-409248-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CHRDL2 siRNA (h) - sc-72891 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CHRDL2 shRNA Plasmid (h) - sc-72891-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CHRDL2 shRNA (h) Lentiviral Particles - sc-72891-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN6089 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6089 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CHRDL2 siRNA (Human) - CRH8562 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHRDL2 - MBS8207895 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Chrdl2 (NM_015424.3) - SHH263429 from Creative biogene

Category siRNA
Species Reactivities Human

Human CHRDL2 siRNA - orb269064 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CHRDL2 shRNA Plasmid (Human) - CHH8562 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CHRDL2 miRNA 3'UTR clone - MiUTR1H-02133 from Creative biogene

Species Reactivities Human
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