| Gene Symbol |
DDAH2
|
| Entrez Gene |
23564
|
| Alt Symbol |
DDAH, DDAHII, G6a, HEL-S-277, NG30
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dimethylarginine dimethylaminohydrolase 2
|
| Other Description |
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2|S-phase protein|dimethylargininase-2|dimethylarginine dimethylaminohydrolase II|epididymis secretory protein Li 277
|
| Swissprots |
A2BEZ7 O95865
|
| Accessions |
AAD18074 BAB63377 CAB46079 EAX03500 EAX03501 EAX03502 O95865 AA297871 AF070667 AAD20973 AF087894 AAP97193 AK026191 AK098671 AK310024 BC001435 AAH01435 BF338733 CB242623 EB387244 FJ224290 ACI45982 XM_011514448 XP_011512750 XM_011547196 XP_011545498 XM_011547610 XP_011545912 XM_011547847 XP_011546149 XM_011548016 XP_011546318 XM_011548205 XP_011546507 XM_011548389 XP_011546691 NM_001303007 NP_001289936 NM_001303008 NP_001289937 NM_013974 NP_039268
|
| Function |
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. {ECO:0000269|PubMed:10493931}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:21898353}. Mitochondrion {ECO:0000269|PubMed:21898353}. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes.
|
| Tissue Specificity |
Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain. {ECO:0000269|PubMed:10493931}.
|