Gene Symbol | DDAH2 |
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Entrez Gene | 23564 |
Alt Symbol | DDAH, DDAHII, G6a, HEL-S-277, NG30 |
Species | Human |
Gene Type | protein-coding |
Description | dimethylarginine dimethylaminohydrolase 2 |
Other Description | N(G),N(G)-dimethylarginine dimethylaminohydrolase 2|S-phase protein|dimethylargininase-2|dimethylarginine dimethylaminohydrolase II|epididymis secretory protein Li 277 |
Swissprots | A2BEZ7 O95865 |
Accessions | AAD18074 BAB63377 CAB46079 EAX03500 EAX03501 EAX03502 O95865 AA297871 AF070667 AAD20973 AF087894 AAP97193 AK026191 AK098671 AK310024 BC001435 AAH01435 BF338733 CB242623 EB387244 FJ224290 ACI45982 XM_011514448 XP_011512750 XM_011547196 XP_011545498 XM_011547610 XP_011545912 XM_011547847 XP_011546149 XM_011548016 XP_011546318 XM_011548205 XP_011546507 XM_011548389 XP_011546691 NM_001303007 NP_001289936 NM_001303008 NP_001289937 NM_013974 NP_039268 |
Function | Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. {ECO:0000269|PubMed:10493931}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21898353}. Mitochondrion {ECO:0000269|PubMed:21898353}. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes. |
Tissue Specificity | Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain. {ECO:0000269|PubMed:10493931}. |
DDAH II CRISPR/Cas9 KO Plasmid (h) - sc-403032 from Santa Cruz Biotechnology
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DDAH II HDR Plasmid (h) - sc-403032-HDR from Santa Cruz Biotechnology
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DDAH II Double Nickase Plasmid (h) - sc-403032-NIC from Santa Cruz Biotechnology
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DDAH II Double Nickase Plasmid (h2) - sc-403032-NIC-2 from Santa Cruz Biotechnology
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DDAH II CRISPR Activation Plasmid (h) - sc-403032-ACT from Santa Cruz Biotechnology
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DDAH II CRISPR Activation Plasmid (h2) - sc-403032-ACT-2 from Santa Cruz Biotechnology
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DDAH II Lentiviral Activation Particles (h) - sc-403032-LAC from Santa Cruz Biotechnology
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DDAH II Lentiviral Activation Particles (h2) - sc-403032-LAC-2 from Santa Cruz Biotechnology
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DDAH II siRNA (h) - sc-40474 from Santa Cruz Biotechnology
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DDAH II shRNA Plasmid (h) - sc-40474-SH from Santa Cruz Biotechnology
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DDAH II shRNA (h) Lentiviral Particles - sc-40474-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU147981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7019 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7019 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01372 from Sigma-Aldrich
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DDAH2 siRNA (Human) - CRH8365 from Cohesion Biosciences
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DDAH2 - MBS8224930 from MyBioSource
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shRNA set against Human DDAH2 (NM_013974.1) - SHH275553 from Creative biogene
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Human DDAH2 siRNA - orb268867 from Biorbyt
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DDAH2 shRNA Plasmid (Human) - CHH8365 from Cohesion Biosciences
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DDAH2 miRNA 3'UTR clone - MiUTR1H-02705 from Creative biogene
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