| Gene Symbol |
RAMP3
|
| Entrez Gene |
10268
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
receptor (G protein-coupled) activity modifying protein 3
|
| Other Description |
CRLR activity-modifying protein 3|calcitonin receptor-like receptor activity modifying protein 3|calcitonin-receptor-like receptor activity-modifying protein 3|receptor (calcitonin) activity modifying protein 3|receptor activity modifying protein 3|receptor activity-modifying protein 3|receptor-activity-modifying protein 3
|
| Swissprots |
Q7Z2Y1 O60896
|
| Accessions |
BAN10197 BAN10198 EAL23743 EAW61048 EAW61049 EAW61050 O60896 AJ001016 CAA04474 AK128765 AK222469 BAD96189 AK311871 BAG34812 AY265459 AAP23300 BC022304 AAH22304 BC053852 AAH53852 BP347072 DQ891371 ABM82297 HQ448585 ADQ33063 XM_006715631 XP_006715694 NM_005856 NP_005847
|
| Function |
Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:9620797}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.
|
| Tissue Specificity |
Strongly expressed in lung, breast, immune system and fetal tissues. {ECO:0000269|PubMed:9620797}.
|
| Top Pathways |
Vascular smooth muscle contraction
|