Gene Symbol | RAMP3 |
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Entrez Gene | 10268 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | receptor (G protein-coupled) activity modifying protein 3 |
Other Description | CRLR activity-modifying protein 3|calcitonin receptor-like receptor activity modifying protein 3|calcitonin-receptor-like receptor activity-modifying protein 3|receptor (calcitonin) activity modifying protein 3|receptor activity modifying protein 3|receptor activity-modifying protein 3|receptor-activity-modifying protein 3 |
Swissprots | Q7Z2Y1 O60896 |
Accessions | BAN10197 BAN10198 EAL23743 EAW61048 EAW61049 EAW61050 O60896 AJ001016 CAA04474 AK128765 AK222469 BAD96189 AK311871 BAG34812 AY265459 AAP23300 BC022304 AAH22304 BC053852 AAH53852 BP347072 DQ891371 ABM82297 HQ448585 ADQ33063 XM_006715631 XP_006715694 NM_005856 NP_005847 |
Function | Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. {ECO:0000269|PubMed:23674134, ECO:0000269|PubMed:9620797}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner. |
Tissue Specificity | Strongly expressed in lung, breast, immune system and fetal tissues. {ECO:0000269|PubMed:9620797}. |
Top Pathways | Vascular smooth muscle contraction |
RAMP3 CRISPR/Cas9 KO Plasmid (h) - sc-402235 from Santa Cruz Biotechnology
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RAMP3 HDR Plasmid (h) - sc-402235-HDR from Santa Cruz Biotechnology
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RAMP3 Double Nickase Plasmid (h) - sc-402235-NIC from Santa Cruz Biotechnology
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RAMP3 Double Nickase Plasmid (h2) - sc-402235-NIC-2 from Santa Cruz Biotechnology
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RAMP3 CRISPR Activation Plasmid (h) - sc-402235-ACT from Santa Cruz Biotechnology
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RAMP3 CRISPR Activation Plasmid (h2) - sc-402235-ACT-2 from Santa Cruz Biotechnology
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RAMP3 Lentiviral Activation Particles (h) - sc-402235-LAC from Santa Cruz Biotechnology
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RAMP3 Lentiviral Activation Particles (h2) - sc-402235-LAC-2 from Santa Cruz Biotechnology
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RAMP3 siRNA (h) - sc-40896 from Santa Cruz Biotechnology
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RAMP3 shRNA Plasmid (h) - sc-40896-SH from Santa Cruz Biotechnology
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RAMP3 shRNA (h) Lentiviral Particles - sc-40896-V from Santa Cruz Biotechnology
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RAMP3 RNAi - H00010268-R01 from Novus Biologicals
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MISSION® esiRNA - EHU010071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17934 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17934 from Sigma-Aldrich
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RAMP3 siRNA (Human) - CRH6951 from Cohesion Biosciences
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RAMP3 - MBS8212780 from MyBioSource
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shRNA set against Human RAMP3 (NM_005856.2) - SHH389424 from Creative biogene
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shRNA set against Human RAMP3(NM_005856.2) - SHR163644 from Creative biogene
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Human RAMP3 siRNA - orb267453 from Biorbyt
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RAMP3 shRNA Plasmid (Human) - CHH6951 from Cohesion Biosciences
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RAMP3 miRNA 3'UTR clone - MiUTR1H-08615 from Creative biogene
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