| Gene Symbol |
Grm1
|
| Entrez Gene |
24414
|
| Alt Symbol |
Gprc1a
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
glutamate receptor, metabotropic 1
|
| Other Description |
G protein coupled receptor family C group 1 member A|mGluR1|metabotropic glutamate receptor 1
|
| Swissprots |
P23385
|
| Accessions |
EDL93710 EDL93711 P23385 M61099 AAA19497 X57569 CAA40799 Y18809 CAB51054 Y18810 CAB51055 Y18811 CAB51056 Y18812 CAB51057 NM_001114330 NP_001107802 NM_017011 NP_058707
|
| Function |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. {ECO:0000269|PubMed:10945991, ECO:0000269|PubMed:1438218, ECO:0000269|PubMed:1656524, ECO:0000269|PubMed:1847995}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:10945991}; Multi-pass membrane protein {ECO:0000269|PubMed:10945991}.
|
| Tissue Specificity |
Predominantly expressed in cerebellar Purkinje cells, CA2-CA3 pyramidal cells of the hippocampus, and mitral and tufted cells of the olfactory bulb. {ECO:0000269|PubMed:1656524, ECO:0000269|PubMed:1847995}.
|
| Top Pathways |
Glutamatergic synapse, Calcium signaling pathway, Long-term depression, Retrograde endocannabinoid signaling, Estrogen signaling pathway
|