Gene Symbol | ELAC1 |
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Entrez Gene | 55520 |
Alt Symbol | D29 |
Species | Human |
Gene Type | protein-coding |
Description | elaC ribonuclease Z 1 |
Other Description | RNase Z 1|RNaseZ(S)|deleted in Ma29|elaC homolog 1|elaC homolog protein 1|ribonuclease Z 1|tRNA 3 endonuclease 1|tRNA 3' processing endoribonuclease|tRNA Z (short form)|tRNase Z 1|tRNase ZS|zinc phosphodiesterase ELAC protein 1 |
Swissprots | Q9H777 Q9NS99 |
Accessions | EAW62983 EAW62984 Q9H777 AB029151 BAA96799 AF308695 AAG24917 AI870985 AK024822 BAB15021 AK223507 BAD97227 AK310911 BC014624 AAH14624 DQ892785 ABM83711 DQ896032 ABM87031 NM_018696 NP_061166 |
Function | Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:21593607}. Nucleus {ECO:0000269|PubMed:21593607}. Note=Mainly cytosolic. |
Tissue Specificity | Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11401430}. |
Top Pathways | RNA transport |
RNase Z1 CRISPR/Cas9 KO Plasmid (h) - sc-412542 from Santa Cruz Biotechnology
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RNase Z1 HDR Plasmid (h) - sc-412542-HDR from Santa Cruz Biotechnology
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RNase Z1 Double Nickase Plasmid (h) - sc-412542-NIC from Santa Cruz Biotechnology
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RNase Z1 Double Nickase Plasmid (h2) - sc-412542-NIC-2 from Santa Cruz Biotechnology
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RNase Z1 CRISPR Activation Plasmid (h) - sc-412542-ACT from Santa Cruz Biotechnology
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RNase Z1 CRISPR Activation Plasmid (h2) - sc-412542-ACT-2 from Santa Cruz Biotechnology
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RNase Z1 Lentiviral Activation Particles (h) - sc-412542-LAC from Santa Cruz Biotechnology
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RNase Z1 Lentiviral Activation Particles (h2) - sc-412542-LAC-2 from Santa Cruz Biotechnology
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RNase Z1 siRNA (h) - sc-76411 from Santa Cruz Biotechnology
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RNase Z1 shRNA Plasmid (h) - sc-76411-SH from Santa Cruz Biotechnology
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RNase Z1 shRNA (h) Lentiviral Particles - sc-76411-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU045421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7793 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7793 from Sigma-Aldrich
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ELAC1 siRNA (Human) - CRJ0723 from Cohesion Biosciences
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ELAC1 RNAi - H00055520-R01 from Novus Biologicals
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ELAC1 - MBS8233911 from MyBioSource
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shRNA set against Human ELAC1 (NM_018696.2) - SHH284913 from Creative biogene
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shRNA set against Human ELAC1(NM_018696.2) - SHH030683 from Creative biogene
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ELAC1 shRNA Plasmid (Human) - CHJ0723 from Cohesion Biosciences
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ELAC1 miRNA 3'UTR clone - MiUTR1H-03185 from Creative biogene
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