| Gene Symbol |
OVOL2
|
| Entrez Gene |
58495
|
| Alt Symbol |
EUROIMAGE566589, ZNF339
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ovo-like zinc finger 2
|
| Other Description |
transcription factor Ovo-like 2|zinc finger protein 339
|
| Swissprots |
Q9Y4M0 Q9BX22 Q5T8B4 Q9BRP0 Q9HA54
|
| Accessions |
EAX10258 EAX10259 Q9BRP0 AI811832 AK022284 BAB14002 AL079276 CAB45151 BC006148 AAH06148 BE791524 BM563561 BT007295 AAP35959 BX331154 DB460914 NM_001303461 NP_001290390 NM_001303462 NP_001290391 NM_021220 NP_067043
|
| Function |
Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. {ECO:0000250, ECO:0000269|PubMed:19700410}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expressed in testis, ovary, heart and skeletal muscle. {ECO:0000269|PubMed:12213202}.
|