Gene Symbol | OVOL2 |
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Entrez Gene | 58495 |
Alt Symbol | EUROIMAGE566589, ZNF339 |
Species | Human |
Gene Type | protein-coding |
Description | ovo-like zinc finger 2 |
Other Description | transcription factor Ovo-like 2|zinc finger protein 339 |
Swissprots | Q9Y4M0 Q9BX22 Q5T8B4 Q9BRP0 Q9HA54 |
Accessions | EAX10258 EAX10259 Q9BRP0 AI811832 AK022284 BAB14002 AL079276 CAB45151 BC006148 AAH06148 BE791524 BM563561 BT007295 AAP35959 BX331154 DB460914 NM_001303461 NP_001290390 NM_001303462 NP_001290391 NM_021220 NP_067043 |
Function | Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. {ECO:0000250, ECO:0000269|PubMed:19700410}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Expressed in testis, ovary, heart and skeletal muscle. {ECO:0000269|PubMed:12213202}. |
Ovol2 CRISPR/Cas9 KO Plasmid (h) - sc-404459 from Santa Cruz Biotechnology
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Ovol2 HDR Plasmid (h) - sc-404459-HDR from Santa Cruz Biotechnology
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Ovol2 Double Nickase Plasmid (h) - sc-404459-NIC from Santa Cruz Biotechnology
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Ovol2 Double Nickase Plasmid (h2) - sc-404459-NIC-2 from Santa Cruz Biotechnology
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Ovol2 CRISPR Activation Plasmid (h) - sc-404459-ACT from Santa Cruz Biotechnology
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Ovol2 CRISPR Activation Plasmid (h2) - sc-404459-ACT-2 from Santa Cruz Biotechnology
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Ovol2 Lentiviral Activation Particles (h) - sc-404459-LAC from Santa Cruz Biotechnology
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Ovol2 Lentiviral Activation Particles (h2) - sc-404459-LAC-2 from Santa Cruz Biotechnology
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Ovol2 siRNA (h) - sc-76022 from Santa Cruz Biotechnology
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Ovol2 shRNA Plasmid (h) - sc-76022-SH from Santa Cruz Biotechnology
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Ovol2 shRNA (h) Lentiviral Particles - sc-76022-V from Santa Cruz Biotechnology
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OVOL2 RNAi - H00058495-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN16212 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16212 from Sigma-Aldrich
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OVOL2 siRNA (Human) - CRJ1725 from Cohesion Biosciences
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shRNA set against Human OVOL2 (NM_021220.2) - SHH369252 from Creative biogene
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shRNA set against Human OVOL2(NM_021220.2) - SHR084064 from Creative biogene
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OVOL2 shRNA Plasmid (Human) - CHJ1725 from Cohesion Biosciences
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OVOL2 miRNA 3'UTR clone - MiUTR1H-07424 from Creative biogene
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