LIN7A

Gene Symbol	LIN7A
Entrez Gene	8825
Alt Symbol	LIN-7A, LIN7, MALS-1, TIP-33, VELI1
Species	Human
Gene Type	protein-coding
Description	lin-7 homolog A (C. elegans)
Other Description	hLin-7|mammalian LIN-7 1|mammalian lin-seven protein 1|protein lin-7 homolog A|tax interaction protein 33|veli-1|vertebrate LIN7 homolog 1|vertebrate lin-7 homolog 1
Swissprots	Q6LES3 A4FTY3 O14910 Q147W1 Q7LDS4
Accessions	EAW97370 EAW97371 O14910 AF028826 AAB84251 AF087693 AAC78481 AF173081 AAD48500 AK022997 AK309256 AK315321 BAG37724 BC041400 BC046926 BC062332 BC099921 AAH99921 BC118609 AAI18610 BC122561 AAI22562 CR407680 CAG28608 XM_011538928 XP_011537230 NM_004664 NP_004655
Function	Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000269|PubMed:12967566}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Basolateral cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Cell junction {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. {ECO:0000250}.
Tissue Specificity	Expressed in brain, testis, kidney, placenta and liver. {ECO:0000269|PubMed:11311936}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LIN7A-Over-expression-Lysate - LY16449a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

LIN7A 293T Cell Transient Overexpression Lysate(Denatured) - H00008825-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

LIN7A overexpression lysate - LY417838 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

LIN7A 293 Cell Lysate - 408351 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species C. elegans

LIN7A Over-expression Lysate Product - GWB-2C99AF from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

LIN7 Overexpression Lysate (Native) - NBP2-10532 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

LIN7 Overexpression Lysate (Denatured) - H00008825-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human LIN7A Knockdown Stable Cell Line - CSC-DC008728 from Creative biogene Category Cell Line Species Human

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