LIN7A

Gene Symbol	LIN7A
Entrez Gene	8825
Alt Symbol	LIN-7A, LIN7, MALS-1, TIP-33, VELI1
Species	Human
Gene Type	protein-coding
Description	lin-7 homolog A (C. elegans)
Other Description	hLin-7|mammalian LIN-7 1|mammalian lin-seven protein 1|protein lin-7 homolog A|tax interaction protein 33|veli-1|vertebrate LIN7 homolog 1|vertebrate lin-7 homolog 1
Swissprots	Q6LES3 A4FTY3 O14910 Q147W1 Q7LDS4
Accessions	EAW97370 EAW97371 O14910 AF028826 AAB84251 AF087693 AAC78481 AF173081 AAD48500 AK022997 AK309256 AK315321 BAG37724 BC041400 BC046926 BC062332 BC099921 AAH99921 BC118609 AAI18610 BC122561 AAI22562 CR407680 CAG28608 XM_011538928 XP_011537230 NM_004664 NP_004655
Function	Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000269|PubMed:12967566}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Basolateral cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Cell junction {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. {ECO:0000250}.
Tissue Specificity	Expressed in brain, testis, kidney, placenta and liver. {ECO:0000269|PubMed:11311936}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Veli1 CRISPR/Cas9 KO Plasmid (h) - sc-406559 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Veli1 HDR Plasmid (h) - sc-406559-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Veli1 Double Nickase Plasmid (h) - sc-406559-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Veli1 Double Nickase Plasmid (h2) - sc-406559-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Veli1 CRISPR Activation Plasmid (h) - sc-406559-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Veli1 CRISPR Activation Plasmid (h2) - sc-406559-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Veli1 Lentiviral Activation Particles (h) - sc-406559-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Veli1 Lentiviral Activation Particles (h2) - sc-406559-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Veli1 siRNA (h) - sc-42316 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Veli1 shRNA Plasmid (h) - sc-42316-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Veli1 shRNA (h) Lentiviral Particles - sc-42316-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU045511 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11733 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11733 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02368 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr02368

LIN7A siRNA (Human) - CRH5823 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Veli1 CRISPR/Cas9 KO Plasmid (h2) - sc-406559-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Veli1 HDR Plasmid (h2) - sc-406559-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human LIN7A (NM_004664.2) - SHH330527 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human LIN7A(NM_004664.2) - SHH150513 from Creative biogene Category siRNA Species Reactivities Human

LIN7A shRNA Plasmid (Human) - CHH5823 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

LIN7A miRNA 3'UTR clone - MiUTR1H-05692 from Creative biogene Species Reactivities Human

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