LIN7A

Gene Symbol	LIN7A
Entrez Gene	8825
Alt Symbol	LIN-7A, LIN7, MALS-1, TIP-33, VELI1
Species	Human
Gene Type	protein-coding
Description	lin-7 homolog A (C. elegans)
Other Description	hLin-7|mammalian LIN-7 1|mammalian lin-seven protein 1|protein lin-7 homolog A|tax interaction protein 33|veli-1|vertebrate LIN7 homolog 1|vertebrate lin-7 homolog 1
Swissprots	Q6LES3 A4FTY3 O14910 Q147W1 Q7LDS4
Accessions	EAW97370 EAW97371 O14910 AF028826 AAB84251 AF087693 AAC78481 AF173081 AAD48500 AK022997 AK309256 AK315321 BAG37724 BC041400 BC046926 BC062332 BC099921 AAH99921 BC118609 AAI18610 BC122561 AAI22562 CR407680 CAG28608 XM_011538928 XP_011537230 NM_004664 NP_004655
Function	Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000269|PubMed:12967566}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Basolateral cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Cell junction {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. {ECO:0000250}.
Tissue Specificity	Expressed in brain, testis, kidney, placenta and liver. {ECO:0000269|PubMed:11311936}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LIN7A full length protein - ab134591 from Abcam Category Protein Source E. coli Species Human

LIN7A Antibody Blocking Peptide - LS-E4867 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LIN7 Recombinant Protein - H00008825-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human LIN7 Protein - NBP2-23197 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

LIN7A-Antibody-C-term-Blocking-Peptide - BP17246b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human LIN7A protein - orb168739 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli

Lin7A protein (His tag) - 80R-2509 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

LIN7A (1-233, His-tag) - AR50581PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

LIN7A (1-233, His-tag) - AR50581PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

LIN7A - H00008825-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

LIN7A - H00008825-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Lin7A, 1-233aa, Human, His tag, E.coli - 01-P1757 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

LIN7A fusion protein - Ag18419 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

LIN7A fusion protein - Ag18440 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Lin7A, 1-233aa, Recombinant Protein - GWB-P0281H from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

Recombinant Human Lin-7 Homolog A (C. elegans), His-tagged - LIN7A-7189H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Protein lin-7 homolog A(LIN7A) - CSB-YP012963HU CSB-EP012963HU CSB-BP012963HU CSB-MP012963HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Lin7A, 1-233aa, Human, His tag, E.coli - ATGP1757 from ATGen Category Protein Prices $105.00, $320.00, $960.00 Sizes 10 µg, 50 µg, 250 µg Species Human

LIN7A Protein (Recombinant) - abx262552 from Abbexa Category Protein

LIN7A - TP321902 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

LIN7A Peptide, Human - M34GP08728H from Creative Peptides Category Peptide Source Synthetic. Species Human

Lin7A - PAT-81758-1 from Nordic BioSite Category Protein Species Human

Lin7A - PAT-81758-2 from Nordic BioSite Category Protein Species Human

LIN7A, Human Recombinant - 228-21359-1 from RayBiotech Category Protein Species Human

LIN7A, Recombinant Protein - MBS145947 from MyBioSource Category Protein Prices $140.00, $205.00, $5,015.00 Sizes 2 µg, 10 µg, 1 mg Source E Coli

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