| Gene Symbol |
HCN1
|
| Entrez Gene |
348980
|
| Alt Symbol |
BCNG-1, BCNG1, EIEE24, HAC-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hyperpolarization activated cyclic nucleotide gated potassium channel 1
|
| Other Description |
brain cyclic nucleotide gated channel 1|brain cyclic nucleotide-gated channel 1|hyperpolarization activated cyclic nucleotide-gated potassium channel 1|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
|
| Swissprots |
O60741
|
| Accessions |
CCF23297 EAW56077 EAW56078 O60741 AF064876 AAC39759 AF488549 AAO49469 AK094523 BC156454 AAI56455 BC172530 AAI72530 BM931647 BX537747 CK299850 DR003732 NM_021072 NP_066550
|
| Function |
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. {ECO:0000269|PubMed:15351778}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15351778}; Multi-pass membrane protein {ECO:0000269|PubMed:15351778}.
|
| Tissue Specificity |
Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas. {ECO:0000269|PubMed:9630217}.
|