SMAD6

Gene Symbol	SMAD6
Entrez Gene	4091
Alt Symbol	AOVD2, HsT17432, MADH6, MADH7
Species	Human
Gene Type	protein-coding
Description	SMAD family member 6
Other Description	MAD homolog 6|SMAD, mothers against DPP homolog 6|mothers against decapentaplegic homolog 6|mothers against decapentaplegic, drosophila, homolog of, 6
Swissprots	Q7Z7L4 Q15799 O43541 Q9UKZ3 A9J6M5 Q96E31 O43654
Accessions	AAF06841 AAF14343 EAW77784 EAW77785 EAW77786 O43541 AF035528 AAB94137 AF037469 AAC82331 AF043640 AAC00497 AM909653 CAP20377 BC012986 AAH12986 BC029288 BC052569 BU154759 CA406301 CB055216 CN314453 CN314455 U59914 AAC50792 XM_011521561 XP_011519863 XR_931825 XR_931826 XR_931827 NM_005585 NP_005576 NR_027654 NM_001142861
Function	Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:16951688, ECO:0000269|PubMed:9436979}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16491121}.
Tissue Specificity	Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Top Pathways	TGF-beta signaling pathway, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Smad6 Antibody - 9519 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

Smad6 (D-4) - sc-25321 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Smad6 (H-150) - sc-13048 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Smad6 (P-20) - sc-26401 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Smad6 (S-20) - sc-6034 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-SMAD6 antibody - ab63713 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SMAD6 antibody - ab55485 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SMAD6 antibody - ab13727 from Abcam Prices $392.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMAD6 antibody [4F3] - ab110156 from Abcam Prices $378.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 4F3

Anti-SMAD6 antibody - Carboxyterminal end - ab80049 from Abcam Prices $370.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody - LS-C89113 from LifeSpan Bioscience Prices $530.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody (C-Terminus) - LS-C144963 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody (aa136-185) - LS-C29802 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody (clone 5H3) - LS-C169247 from LifeSpan Bioscience Prices $345.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5H3

Anti-SMAD6 Antibody (aa357-386, AP) - LS-C269632 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody (aa137-182) - LS-C31183 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody (aa357-386, Biotin) - LS-C269633 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody (aa357-386, APC) - LS-C269634 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody (aa357-386) - LS-C156110 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody (aa357-386, FITC) - LS-C269635 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody (aa357-386, PE) - LS-C269637 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody (aa357-386, Azide-free, HRP) - LS-C269636 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody (aa366-396, AP) - LS-C269638 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody (aa11-60) - LS-C205643 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SMAD6 Antibody (aa366-396, APC) - LS-C269639 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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