SMAD6

Gene Symbol	SMAD6
Entrez Gene	4091
Alt Symbol	AOVD2, HsT17432, MADH6, MADH7
Species	Human
Gene Type	protein-coding
Description	SMAD family member 6
Other Description	MAD homolog 6|SMAD, mothers against DPP homolog 6|mothers against decapentaplegic homolog 6|mothers against decapentaplegic, drosophila, homolog of, 6
Swissprots	Q7Z7L4 Q15799 O43541 Q9UKZ3 A9J6M5 Q96E31 O43654
Accessions	AAF06841 AAF14343 EAW77784 EAW77785 EAW77786 O43541 AF035528 AAB94137 AF037469 AAC82331 AF043640 AAC00497 AM909653 CAP20377 BC012986 AAH12986 BC029288 BC052569 BU154759 CA406301 CB055216 CN314453 CN314455 U59914 AAC50792 XM_011521561 XP_011519863 XR_931825 XR_931826 XR_931827 NM_005585 NP_005576 NR_027654 NM_001142861
Function	Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:16951688, ECO:0000269|PubMed:9436979}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16491121}.
Tissue Specificity	Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Top Pathways	TGF-beta signaling pathway, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SMAD6 peptide - ab66351 from Abcam Category Peptide

Human SMAD6 protein fragment - ab158843 from Abcam Category Protein Source Wheat germ Species Human

SMAD6 Antibody Blocking Peptide - LS-E10781 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMAD6 Antibody Blocking Peptide - LS-E7824 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMAD6 Recombinant Protein - H00004091-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SMAD6-Antibody-Center-Blocking-peptide - BP5344c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMAD6 peptide - orb217574 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Human Smad6 Protein - abx068080 from Abbexa Category Protein Source E.coli Species Human

SMAD6 Blocking Peptide - abx062905 from Abbexa Category Peptide Species Human, Mouse, Rat

SMAD6 - H00004091-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SMAD6 - H00004091-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SMAD6 fusion protein - Ag13128 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human SMAD6, His-tagged - SMAD6-2801H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Mothers Against Decapentaplegic Homolog 6 (Smad6) - RPC120Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Mothers Against Decapentaplegic Homolog 6 (Smad6) - RPC120Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Mothers Against Decapentaplegic Homolog 6 (Smad6) - RPC120Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

SMAD6 Blocking Peptide - CBP1711 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Smad6 (N372) Peptide - BS3555P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Mothers Against Decapentaplegic Homolog 7 (Smad7) - RPA648Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Mothers Against Decapentaplegic Homolog 6 (Smad6) - RPC120Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Mothers against decapentaplegic homolog 6(SMAD6) - CSB-YP021792HU CSB-EP021792HU CSB-BP021792HU CSB-MP021792HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Mothers Against Decapentaplegic Homolog 6 (Smad6) - RPU142812 from Biomatik Category Protein Prices $220.00, $440.00, $660.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

SMAD6-Blocking-Peptide-C-term - BP20196b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMAD6 Peptide, Human - M34GP14716H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Mothers Against Decapentaplegic Homolog 6 (Smad6) - RPU42812 from Biomatik Category Protein Prices $176.00, $360.00, $550.00, $656.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

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