SMAD6

Gene Symbol	SMAD6
Entrez Gene	4091
Alt Symbol	AOVD2, HsT17432, MADH6, MADH7
Species	Human
Gene Type	protein-coding
Description	SMAD family member 6
Other Description	MAD homolog 6|SMAD, mothers against DPP homolog 6|mothers against decapentaplegic homolog 6|mothers against decapentaplegic, drosophila, homolog of, 6
Swissprots	Q7Z7L4 Q15799 O43541 Q9UKZ3 A9J6M5 Q96E31 O43654
Accessions	AAF06841 AAF14343 EAW77784 EAW77785 EAW77786 O43541 AF035528 AAB94137 AF037469 AAC82331 AF043640 AAC00497 AM909653 CAP20377 BC012986 AAH12986 BC029288 BC052569 BU154759 CA406301 CB055216 CN314453 CN314455 U59914 AAC50792 XM_011521561 XP_011519863 XR_931825 XR_931826 XR_931827 NM_005585 NP_005576 NR_027654 NM_001142861
Function	Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:16951688, ECO:0000269|PubMed:9436979}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16491121}.
Tissue Specificity	Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Top Pathways	TGF-beta signaling pathway, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mothers against decapentaplegic homolog 6 (SMAD6), Human, ELISA Kit - CSB-EL021792HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Mothers against decapentaplegic homolog 6, SMAD6, Human, ELISA Kit - E2187h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Mothers Against Decapentaplegic Homolog 7 (Smad7), Human, ELISA Kit - SEA648Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.056ng/mL Range 0.156-10ng/mL

SMAD6 (Human) IP-WB Antibody Pair - H00004091-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human Mothers against decapentaplegic homolog 6(SMAD6) ELISA kit - CSB-EL021792HU from Cusabio Category ELISA Kit Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

ELISA Kit for Mothers Against Decapentaplegic Homolog 7 (Smad7) - SEA648Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human SMAD6 ELISA Kit (Custom ELISA) - LS-F19445 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Chicken SMAD6 ELISA Kit (Custom ELISA) - LS-F19446 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Mouse SMAD6 ELISA Kit (Custom ELISA) - LS-F19447 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range To be determined

SMAD family member 6, ELISA Kit - MBS945031 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 3.9 pg/ml. Range 15.6 pg/ml -1000 pg/ml.

Human Smad6/MADH6(Mothers Against Decapentaplegic Homolog 6) ELISA Kit - E-EL-H5629 from Elabscience Category ELISA Kit Sensitivity 37.50 pg/mL Range 62.50—4000 pg/mL

Mothers Against Decapentaplegic Homolog 6, Smad6/MADH6, Human, ELISA Kit - E-EL-H5629 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 37.5 Range 62.5-4000pg/mL

Human Mothers against decapentaplegic homolog 6 (SMAD6) ELISA Kit - EKC34647 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Human Smad6/MADH6 ELISA Kit - E024934 from Biobool Category ELISA Kit Sensitivity 37.5

Human SMAD6 ELISA Kit - E024935 from Biobool Category ELISA Kit

anti-SMAD6 antibody - ARG55591 from Arigo Biolaboratories Category ELISA Kit

Human Smad6/MADH6(Mothers Against Decapentaplegic Homolog 6) ELISA Kit - E-EL-H5629 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 37.5 pg/mL Range 62.5~4000 pg/mL

Human Mothers against decapentaplegic homolog 9 (SMAD9) ELISA Kit - AE18162HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.061 ng/mL Range 0.156-10 ng/mL

Mothers Against Decapentaplegic Homolog 6, ELISA Kit - MBS2533444 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

Mothers against decapentaplegic homolog 6, ELISA Kit - MBS289534 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human SMAD6 ELISA Kit - orb404854 from Biorbyt Category ELISA Kit Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

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