SMAD6

Gene Symbol	SMAD6
Entrez Gene	4091
Alt Symbol	AOVD2, HsT17432, MADH6, MADH7
Species	Human
Gene Type	protein-coding
Description	SMAD family member 6
Other Description	MAD homolog 6|SMAD, mothers against DPP homolog 6|mothers against decapentaplegic homolog 6|mothers against decapentaplegic, drosophila, homolog of, 6
Swissprots	Q7Z7L4 Q15799 O43541 Q9UKZ3 A9J6M5 Q96E31 O43654
Accessions	AAF06841 AAF14343 EAW77784 EAW77785 EAW77786 O43541 AF035528 AAB94137 AF037469 AAC82331 AF043640 AAC00497 AM909653 CAP20377 BC012986 AAH12986 BC029288 BC052569 BU154759 CA406301 CB055216 CN314453 CN314455 U59914 AAC50792 XM_011521561 XP_011519863 XR_931825 XR_931826 XR_931827 NM_005585 NP_005576 NR_027654 NM_001142861
Function	Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:16951688, ECO:0000269|PubMed:9436979}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16491121}.
Tissue Specificity	Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Top Pathways	TGF-beta signaling pathway, Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SMAD6 ORF Clone(NM_005585.4) - CDCR290840 from Creative Biomart Species Human Accession NM_005585.4

Human SMAD6 ORF Clone(NM_005585.4) - CDCR290841 from Creative Biomart Species Human Accession NM_005585.4

Human SMAD6 ORF Clone(NM_001142861.2) - CDCL176335 from Creative Biomart Species Human Accession NM_001142861.2

Human SMAD6 ORF Clone(NM_001142861.2) - CDCL176336 from Creative Biomart Species Human Accession NM_001142861.2

human SMAD6 ORF clone - CDCH083334 from Creative Biomart Species Human Accession NM_001142861

human SMAD6 ORF clone - CDCH083335 from Creative Biomart Species Human Accession NM_001142861

human SMAD6 ORF clone - CDCH083336 from Creative Biomart Species Human Accession NM_001142861

human SMAD6 ORF clone - CDCH083337 from Creative Biomart Species Human Accession NM_001142861

human SMAD6 ORF clone - CDCH083338 from Creative Biomart Species Human Accession NM_001142861

human SMAD6 ORF clone - CDCH083339 from Creative Biomart Species Human Accession NM_001142861

human SMAD6 ORF clone - CDCH083340 from Creative Biomart Species Human Accession NM_001142861

human SMAD6 ORF clone - CDCH083341 from Creative Biomart Species Human Accession NM_001142861

human SMAD6 ORF clone (NM_001142861.2) - CDCH083336 from Creative biogene Species Human

human SMAD6 ORF clone (NM_005585.4) - CDCH083338 from Creative biogene Species Human

Human SMAD9 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG12311-ACR from Sino Biological Species Human

Human SMAD9 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG12311-ANR from Sino Biological Species Human

Search more