| Gene Symbol |
SMAD6
|
| Entrez Gene |
4091
|
| Alt Symbol |
AOVD2, HsT17432, MADH6, MADH7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SMAD family member 6
|
| Other Description |
MAD homolog 6|SMAD, mothers against DPP homolog 6|mothers against decapentaplegic homolog 6|mothers against decapentaplegic, drosophila, homolog of, 6
|
| Swissprots |
Q7Z7L4 Q15799 O43541 Q9UKZ3 A9J6M5 Q96E31 O43654
|
| Accessions |
AAF06841 AAF14343 EAW77784 EAW77785 EAW77786 O43541 AF035528 AAB94137 AF037469 AAC82331 AF043640 AAC00497 AM909653 CAP20377 BC012986 AAH12986 BC029288 BC052569 BU154759 CA406301 CB055216 CN314453 CN314455 U59914 AAC50792 XM_011521561 XP_011519863 XR_931825 XR_931826 XR_931827 NM_005585 NP_005576 NR_027654 NM_001142861
|
| Function |
Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:16951688, ECO:0000269|PubMed:9436979}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16491121}.
|
| Tissue Specificity |
Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
|
| Top Pathways |
TGF-beta signaling pathway, Endocytosis
|
![Western Blot: SMAD6 Overexpression Lysate (Adult Normal) [NBP2-09672] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SMAD6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3155_SMAD6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09672-img0001.jpg)